Effect of Combination of Carbopol-940 Base and HPMC Gel Extract of Aloe Vera Flesh on Physical Properties and Antibacterial Activity of Propionibacterium acnes

ABSTRACT Aloe vera (Aloe chinensis Barker.) has been shown to be efficacious as an antibacterial which the potential treat acne caused by bacteria Propionibacterium acnes. The use of this combination can increase viscosity, dissolution, diffusion, and bioavailability preparation. This study aims determine effect Carbopol base HPMC a gelling agent on physical properties activity aloe gel against P. acnes bacteria. flesh extract was obtained using 70% ethanol maceration method. preparation active substance concentration 0.50% Carbopol:HPMC with ratio 1.00:0.50; 0.75:0.75; 0.50:1.00. tests included adhesion, dispersibility, viscosity well measurement measuring diameter inhibition zone formed media. resulting data from were analyzed linear regression correlation. While results statistical ANOVA showed that increasing HPMC, adhesive power decreased, but dispersion increased. three formulations had different zones due differences in diffusion occurred test medium. Keywords: Vera, Gel, Acnes.